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打击食品传播的MRSA:识别和基于银纳米粒子的抗菌策略与抗生素协同作用和耐药性进化评估

Adil Abalkhail¹, Eman Marzouk¹

¹Department of Public Health, College of Applied Medical Sciences, Qassim University, P.O. Box 6666, Buraydah 51452, Saudi Arabia.

|October 29, 2025

概括

准备好吃的食品可能含有耐甲基金色葡萄球菌 (MRSA). 这项研究在6.7%的产品中发现了MRSA,强调了快速监测和新型干预措施的需要,如银纳米颗粒.

科学领域:

微生物学与食品安全
抗微生物药物耐药性的监测和监测
纳米技术在医学中的应用

背景情况:

准备食用 (RTE) 食品是抗微生物耐药病原体的潜在载体,包括耐甲基黄金葡萄球菌 (MRSA).
有限的研究将食品中的真实世界病原体监测与实际干预策略联系起来.

研究的目的:

来自Al-Qassim的RTE食品中估计金黄色葡萄球菌 (金黄色葡萄球菌) 和MRSA的流行率.
评估MRSA检测的快速,直角确认工作流程.
评估酸盐稳定银纳米颗粒 (AgNPs) 作为现有抗生素对食品衍生MRSA的潜在辅助剂的有效性.

主要方法:

调查了149种针对S. aureus和MRSA的RTE产品.
采用了一个工作流:培养 → MALDI-TOF MS → Vitek 2 → mecA/mecC PCR进行确认.
量化了AgNP与牛素和西普罗夫洛素对MRSA的体外活性和协同作用.

主要成果:

在RTE产品中,S. aureus从24.2%中恢复,MRSA从6.7%中恢复,动物来源食品和街头小贩的比例更高.
MALDI-TOF MS使得物种能够快速确认,并确定了潜在的MRSA光谱标记物.
AgNPs显示对MRSA强烈的杀菌活性 (MIC 8-32μg/mL) 和频繁与西林的协同作用 (FICI中位数为0.37),减少了西林MICs 4-16倍.

结论:

RTE食品是MRSA暴露的可信途径,需要综合监测系统.
一个MALDI辅助的选工作流程与自动化抗微生物敏感性测试 (AST) 结合,提供可扩展的监测.
标准化的AgNP配方显示出作为β-乳酸辅助剂对抗食品传播的MRSA的前景,等待进一步评估.

关键词:

黄金葡萄球菌黄金葡萄球菌抗生素协同作用抗生素协同作用甲基西林耐药的金黄色葡萄球菌公共卫生公共卫生.准备好吃的食物是可以吃的.银纳米颗粒的使用方法

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