益生菌及其后生物代谢物在COVID-19后综合征中的作用
Monika E Jach1, Ewa Sajnaga2, Marharyta Bumbul3
1Department of Molecular Biology, Medical Faculty, The John Paul II Catholic University of Lublin, Konstantynów Street 1I, 20-708 Lublin, Poland.
Molecules (Basel, Switzerland)
|October 29, 2025
概括
益生菌和后生菌通过调节肠-大脑轴和表现出抗病毒性质,有望缓解长期COVID症状. 需要进一步的研究来优化它们在COVID后恢复策略中的使用.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 后COVID-19综合征 (长期COVID) 呈现出持续的多器官症状,包括疲劳和神经认知问题.
- 肠道微生物群失调和肠-大脑轴的破坏与长期COVID病理生理学有关.
- 益生菌和后生菌因其免疫调节和抗炎作用而被探索其治疗潜力.
研究的目的:
- 审查益生菌及其代谢物 (后生菌) 的抗病毒机制.
- 讨论后生物质,特别是短链脂肪酸 (SCFA) 在COVID后恢复中的作用.
- 为突出特定益生菌物种缓解长期COVID症状的临床试验.
主要方法:
- 对当前对益生菌抗病毒机制的理解进行文献综述.
- 分析关键的后生物因素,如SCFA,乳酸和细菌素.
- 关于益生菌的临床证据摘要,比如 *Lactiplantibacillus plantarum*, *Lacticaseibacillus rhamnosus* 和 *Bifidobacterium longum*. 这类益生菌的临床证据
主要成果:
- 益生菌采用强化肠道屏障,直接抑制病毒和免疫调节等机制.
- 短链脂肪酸 (SCFA) 被确定为恢复的关键后生物化合物.
- 特定的益生菌菌株显示出缓解长期COVID症状的潜力,尽管需要进一步调查.
结论:
- 益生菌和后生菌为管理长期COVID症状提供了一个有希望的途径.
- 了解特定的菌株,剂量和机制对于有效的治疗策略至关重要.
- 持续的研究对于充分阐明益生菌在COVID后恢复中的作用至关重要.
关键词:
这就是SARS-CoV-2病毒.在SCFAs中,SCFAs是最重要的.抗病毒机制 抗病毒机制肠大脑轴 肠大脑轴肠肺轴 肠肺轴 肠肺轴 肠肺轴长时间的COVID.我们的微生物群.在后COVID时期.这是后急性COVID-19综合征.后生物学的后生物.益生菌是一种益生菌.更多相关视频
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