狼性炎中的生物标志物:基于证据的全面审查
Alexandra Vrabie1, Bogdan Obrișcă1,2, Bogdan Marian Sorohan1,3
1Department of Nephrology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Life (Basel, Switzerland)
|October 29, 2025
概括
狼性炎 (LN) 诊断仍然依赖于传统的生物标志物,如抗dsDNA和蛋白尿. 虽然新型生物标志物显示出希望,但没有一种生物标志物取代了当前的方法,这凸显了在临床实践中进一步验证的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 狼性炎 (LN) 显著影响患者的死亡率和发病率.
- 生物标志物对于较少的侵入性LN评估和个性化医学至关重要.
研究的目的:
- 审查关于尿路和血清生物标志物的LN诊断,活性,治疗反应和结局的研究.
- 总结过去十年的发现,强调传统工具.
主要方法:
- 系统审查过去十年发表的研究.
- 专注于LN的成年患者的尿路和血清生物标志物.
- 强调与传统的诊断和监测工具进行比较.
主要成果:
- 传统的生物标志物包括蛋白尿,尿沉积物,eGFR,抗dsDNA,抗C1q和补充水平.
- 抗dsDNA,C3和蛋白尿是具有中度预测能力的常规生物标志物.
- 像ALCAM,CD163,CXCL10,MCP-1,NGAL,TWEAK和VCAM-1这样的新生物标志物显示出潜力,但需要验证.
结论:
- 在临床实践中,没有新的生物标志物可以取代临床实践中的传统生物标志物来评估LN.
- 需要在独立队列中进一步验证新生物标志物,并与组织学进行整合.
- 目前的LN管理仍然依赖于已建立的生物标志物进行非侵入性评估和治疗指导.
相关概念视频
Nephrotic Syndrome II : Assessment and Medical Management
192
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
192
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
531
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
531
Nephrotic Syndrome I : Introduction
488
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
488
Acute Kidney Injury IV: Diagnostic Studies and Prevention
256
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
256
Nephrotic Syndrome III : Nursing Management
277
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
277
Serum Studies: Renal Function Tests
359
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
359


