在非传染性疾病中的肠道微生物群-性免疫轴
Mario Caldarelli1,2, Pierluigi Rio1,2, Laura Franza2,3
1Department of Translational Medicine and Surgery, Catholic University of Sacred Heart, 00168 Rome, Italy.
Life (Basel, Switzerland)
|October 29, 2025
概括
生物性别影响肠道微生物群 (GM),影响非传染性疾病 (NCD). 了解这种性肠微生物群轴对于开发个性化的NCD预防和治疗策略至关重要.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 健康中的性别差异
背景情况:
- 非传染性疾病 (NCD) 是全球领先的健康负担.
- 肠道微生物群 (GM) 在宿主健康中起着至关重要的作用,包括免疫调节和代谢平衡.
- 新出现的证据表明,生物性别显著影响转基因成分和功能,可能解释疾病易感性和进展的基于性别的差异.
研究的目的:
- 探索生物性对肠道微生物群的影响.
- 研究性肠道微生物群轴在非传染性疾病 (NCD) 中的作用.
- 强调在微生物组研究中需要进行性别分层研究.
主要方法:
- 审查临床和实验研究检查的性别差异在转基因.
- 分析性激素,遗传学,生活方式和转基因之间的相互作用.
- 对性别特异性转基因代谢物及其影响的检查.
主要成果:
- 性激素影响转基因多样性和炎症反应 (雌激素一般具有抗炎作用,雄激素具有炎症作用).
- 转基因代谢物,如短链脂肪酸和胆酸,对炎症和免疫有性别特异的影响.
- 人类研究经常被混,需要谨慎的解释和进一步的机械研究.
结论:
- 性-肠道微生物群轴越来越多地得到证据的支持,影响了NCD的发展.
- 目前的人类研究在很大程度上是横截面的,缺乏机械深度和性别特异性的考虑.
- 未来的研究应该专注于纵向,性别分层,多学科的研究,以阐明个性化NCD策略的因果途径.
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