在献血者的血液中,四年来抗SARS-CoV-2抗体的发展
Christoph Niederhauser1,2,3, Nadja Widmer1, Caroline Tinguely1
1Interregional Blood Transfusion SRC, 3008 Bern, Switzerland.
Viruses
|October 29, 2025
概括
瑞士的献血者显示SARS-CoV-2抗体水平上升,反映了疫苗接种和Omicron变种的传播. 这表明献血者是献血者.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 献血者作为一个有价值的哨兵人口来监测一般人口的健康趋势.
- 了解SARS-CoV-2血清流行对于评估人口免疫力和流行病影响至关重要.
研究的目的:
- 在瑞士献血者群体中调查抗SARS-CoV-2抗体 (抗NCP和抗S) 的血清流行率.
- 评估献血者群体作为感染监测的哨兵系统.
主要方法:
- 在瑞士献血者的横截面血清流行调查.
- 检测针对SARS-CoV-2核蛋白 (NCP) 和 (S) 蛋白的抗体.
- 数据收集时间从2020年3月开始到2023年底.
主要成果:
- 从2020年3月到2021年1月,抗NCP和抗S血清流行率 (~17%) 适度增加.
- 到2021年5月/6月观察到血清流行率显著上升 (抗NCP21.6%,抗S59.4%),与初始疫苗接种保持一致.
- 截至2021年11月-12月至2022年8月,反NCP (74.6%) 的大幅增加,与Omicron变种传播和废除口罩任务相吻合.
- 血清流行率在2022年底达到高水平 (抗S99.0%,抗NCP83.9%),并在2023年底进一步增加 (抗S99.8%,抗NCP95.0%).
结论:
- 瑞士的献血者群体准确地反映了SARS-CoV-2感染动态,包括疫苗接种和变种的影响.
- 献血者监测提供了一种可靠的方法来追踪一般人群中的感染率.
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