血蛋白质组阿尔茨海默氏症风险评分:生物年龄钟和伪时轨迹
Shiwei Liu1,2, Yen-Ning Huang1,2, Tamina Park1,2
1Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|October 29, 2025
概括
来自血蛋白质组的新阿尔茨海默病 (AD) 风险评分,包括老龄化时钟和伪时代,显示出希望. 这些标志物与AD诊断和生物标志物相关,有可能改善早期检测.
科学领域:
- 神经科学是一个神经科学.
- 蛋白质组学是指蛋白质组学.
- 生物标志物发现发现
背景情况:
- 阿尔茨海默病 (AD) 的特点是渐进性的认知能力下降.
- 血蛋白质组学为AD风险和潜在机制提供了潜在的见解.
研究的目的:
- 开发和验证使用等离子体蛋白质学的新型阿尔茨海默病 (AD) 风险评分.
- 评估这些分数与现有的AD生物标志物和诊断性能之间的关联.
主要方法:
- 通过 SomaScan 7k 平台,利用了来自 498 个人的血蛋白质组学数据.
- 基于蛋白质组学计算的AD风险得分,包括器官特定的衰老时钟和伪时间轨迹.
- 研究了与等离子体和成像生物标记物的关联,并评估了用于诊断的分类性能.
主要成果:
- 认知优化的大脑和肝脏衰老加速与AD诊断和生物标志物有显著的相关性.
- 伪物质分析揭示了从正常认知到AD的分子轨迹,与生物标志物相关.
- 结合基于蛋白质组学的风险评分,与仅使用已知等离子体生物标志物相比,提高了分类性能.
结论:
- 蛋白质学衍生生物衰老时钟和伪时轨迹显示出作为AD的补充生物标志物的潜力.
- 这些新型标记物可以帮助识别疾病机制并改善早期检测策略.
- 伪物质分析表明,与现有的血生物标志物相比,诊断分类性能优越.
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