[焦虑和抑郁症状对牙周炎的影响基于孟德尔随机化研究]
Deng Lei1, Yingbin Zhou, Sihui Huang
1Department of Stomatology, The Fourth Hospital of Changsha. Changsha 410006, Hunan Province, China.
Shanghai kou qiang yi xue = Shanghai journal of stomatology
|October 29, 2025
概括
焦虑和抑郁症显著增加牙周炎的风险,特别是急性形式. 在牙周炎患者的临床治疗策略中,应考虑心理因素.
科学领域:
- 口腔健康研究 口腔健康研究
- 精神病学流行病学精神病学流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 牙周炎是一种常见的口腔疾病,具有复杂的病因.
- 焦虑和抑郁是普遍存在的心理健康状况.
- 心理健康和牙周炎之间的关系需要进一步研究.
研究的目的:
- 评估焦虑和抑郁对牙周炎风险的影响,使用孟德尔随机化.
- 分析牙周炎患者焦虑和抑郁的患病率和风险因素.
- 为临床预防和治疗牙周炎提供证据.
主要方法:
- 病例对照研究比较了70名牙周炎患者和35名对照人群.
- 使用汉密尔顿焦虑评分表 (HAMA) 和汉密尔顿抑郁评分表 (HAMD) 评估焦虑和抑郁.
- 使用全基因组关联研究 (GWAS) 数据和五种MR方法,包括逆方差加权 (IVW) 的门德尔随机化分析.
主要成果:
- 牙周炎患者的HAMA和HAMD得分显著提高,焦虑和抑郁的发病率增加.
- 焦虑,抑郁和60岁以上的年龄被确定为牙周炎的独立风险因素.
- 门德尔的随机化表明,急性牙周炎与焦虑和抑郁之间存在正相关性,但慢性牙周炎没有.
结论:
- 焦虑,抑郁和牙周炎之间存在显著的相关性.
- 心理因素起着至关重要的作用,应纳入牙周炎的临床管理.
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