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通过诱导M2巨细胞极化,PROS1/AXL信号保护小鼠免受致命的流感感染

Wenbo Zhu¹, Shao Wang², Shuangquan Liu³

¹The First Affiliated Hospital, Clinical Medical Research Center, Hengyang Medical School, University of South China, Hengyang 421001, China.

Acta biochimica et biophysica Sinica

|October 29, 2025

概括

该研究表明,PROS1/AXL信号通过激活巨细胞来保护小鼠免受致命的流感A病毒 (IAV) 感染和肺部损伤. 这一途径可能是IAV的新治疗点.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
分子生物学分子生物学

背景情况:

AXL受体氨酸激酶在肺组织中表达,并参与病毒感染和肺损伤.
PROS1是一种激活AXL并充当免疫调节器的配体.
在A型流感病毒 (IAV) 感染和肺损伤中,PROS1/AXL信号的作用尚不清楚.

研究的目的:

研究PROS1/AXL信号传导在IAV感染和感染引起的肺损伤中的作用.
为了确定PROS1的管理是否可以防止致命的IAV感染和肺部损伤.

主要方法:

在IAV感染的小鼠模型中对PROS1的外源性给药.
在膜巨细胞中分析了AXL酸化,Gab1招募和PI3K/AKT/mTOR通路激活.
评估巨细胞极化 (M2表型) 和其在保护中的作用,使用Gab1敲击和PI3K抑制 (LY294002).

主要成果:

给予PROS1减轻了肺损伤,并保护小鼠免受致命的IAV感染.
PROS1激活了AXL,导致Gab1和PI3K/AKT/mTOR通路在膜巨细胞中的激活.
通过Gab1激活,PROS1/AXL信号诱导了M2巨细胞的两极分化,这对保护作用至关重要.

结论:

PROS1/AXL信号激活了巨细胞中的Gab1,促进了M2极化,并为致命的IAV感染提供了保护.
PROS1/AXL通路代表了管理IAV感染和相关的肺损伤的潜在治疗标.

关键词:

一个AXL一个AXL 这就是PROS1的意义.流感感染流感感染巨细胞是一个巨细胞.两极分化是一种极化.

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