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康伯塞普与577nm小值微脉冲激光相结合,用于糖尿病黄斑胀

Ying Han¹, Ming-Yuan Yang², Han-Lin Wang³

¹Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China.

International journal of ophthalmology

|October 29, 2025

概括

将conbercept与下值微脉冲激光器 (STML) 结合起来,比单独使用conbercept更有效地改善糖尿病黄斑 (DME) 的结果. 这种组合疗法还需要更少的静脉内注射来治疗DME.

科学领域:

眼科医生眼科眼科
视网膜疾病视网膜疾病
医疗技术医疗技术医学技术

背景情况:

糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
目前对DME的治疗包括抗血管内皮生长因子 (抗VEGF) 治疗和激光光凝.
评估新的治疗组合对于改善DME管理至关重要.

研究的目的:

评估将conbercept与577nm下值微脉冲激光器 (STML) 结合用于DME治疗的疗效和安全性.
为了比较DME患者的组合治疗与conbercept单一治疗的结果.

主要方法:

一项涉及72名DME患者的回顾性研究,从2022年10月到2024年3月.
患者被分为两个组:康伯塞普单一疗法和组合疗法 (康伯塞普+577nm STML).
关键的结果措施包括最佳校正的视力敏度 (BCVA),中央黄斑厚度 (CMT),叶无血管区 (FAZ),视网膜平均灵敏度 (RMS) 和血管密度 (SCP/DCP).

主要成果:

与基线相比,两组治疗都显示了BCVA,CMT,深毛细血管 (DCP) 血管密度和RMS的显著改善.
组合组在BCVA,CMT,DCP血管密度和RMS方面表现出优异的结果,在治疗后3个月和6个月,与仅服用conbercept的组相比.
组合组所需的注射量比单一治疗组少 (3.33±0.68) (4.06±0.96),不显着增加不良事件.

结论:

与conbercept单独治疗相比,与STML结合的Conbercept在DME治疗中提供了更好的疗效.
这种组合疗法可改善DME患者的视觉敏度和视网膜结构.
综合方法减少了必要的内注射的数量,提高了治疗效率.

关键词:

在577nm的微脉冲激光下,微脉冲激光具有下值.这就是Conbercept的概念.糖尿病性黄斑胀糖尿病性黄斑胀光学连贯性断层扫描血管图谱

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