年龄调整的内脏脂肪指数 (AVAI) 与妇科恶性瘤之间的关联:基于NHANES数据的横截面研究
Xincheng Zhang1, Yanran He1, Yujie Hui1
1Department of Gynaecology and Obstetrics, Beijng Friendship Hospital Pinggu Campus, Capital Medical University, Beijing, China.
Translational cancer research
|October 29, 2025
概括
经年龄调整的内脏脂肪指数 (AVAI) 与更高的妇科癌症风险有关,特别是宫癌. 该指数显示,早期检测和干预策略在妇女健康方面是有前途的.
科学领域:
- 妇科瘤学 妇科瘤学
- 代谢健康 代谢健康
- 流行病学 流行病学
背景情况:
- 肥胖和代谢功能障碍是妇科癌症的关键风险因素.
- 像BMI这样的传统指标不能完全评估内脏脂肪,这是癌症发展的关键因素.
- 经年龄调整的内脏脂肪指数 (AVAI) 提供了潜在的更好的内脏脂肪测量.
研究的目的:
- 评估AVAI与患妇科癌症的风险之间的关联.
- 将AVAI的有效性与风险分层中的BMI等传统措施进行比较.
主要方法:
- 从NHANES (2007-2018) 中对7,855名妇女进行横截面分析,其中237名妇女患有妇科癌症.
- 使用多变量逻辑回归和通用添加模型来评估AVAI-妇科癌症风险关联,控制混因素.
- 使用子组分析,受限立方线和ROC曲线来检查剂量反应趋势和差异性表现.
主要成果:
- 与对照组相比,在患有妇科癌症的妇女中观察到较高的AVAI水平.
- 每个AVAI单位的增加都与28%的妇科恶性瘤风险增加有关 (OR=1.280).
- 在宫癌中发现了显著的关联和剂量反应趋势,AVAI显示出强烈的辨别能力 (AUC=0.807).
结论:
- AVAI与妇科癌症,特别是子宫癌的风险有显著的相关性.
- 在妇科癌症中,AVAI在代谢-炎症风险分层方面表现出优于BMI的优势.
- 对于妇科恶性瘤的早期识别和干预策略来说,AVAI是一个新的目标.
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