用azelastine-fluticasone鼻喷雾灌鼻盐水在中度至重的持续过敏鼻炎:一个随机对照试验
Song Li1, Rui Xu2, Shaoqing Yu3
1Department of Otorhinolaryngology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Frontiers in allergy
|October 29, 2025
概括
在标准治疗中添加鼻灌显著改善了中度至重度持久性过敏性鼻炎 (PAR) 患者的症状. 这种组合疗法提供了增强的缓解,并与过敏性鼻炎管理的可比安全性.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 持续性过敏性鼻炎 (PAR) 给症状控制带来了挑战,特别是当鼻内皮质类固醇不足时.
- 对于中度至重度的PAR,急需更有效的治疗选择.
- 这项研究调查了将鼻水灌注添加到现有治疗方法的疗效.
研究的目的:
- 为了评估鼻盐水灌是否可以改善中度至重度PAR患者的症状控制.
- 为了比较与azelastine-fluticasone (Aze-Flu) 结合鼻水灌的疗效与标准治疗.
主要方法:
- 一个多中心,随机,开放的标签试验包括248名患者 (年龄≥12岁).
- 参与者被分配接受鼻注水加Aze-Flu或标准的azelastine和fluticasone鼻喷雾剂.
- 测量结果包括四周内全鼻症状评分 (TNSS),鼻镜,视觉模拟尺度 (VAS) 和生活质量 (RQLQ) 的变化.
主要成果:
- 两组治疗均显示TNSS与基线相比显著减少.
- 与对照组相比,使用Aze-Flu灌鼻盐水的组在两周和四周内在TNSS中表现出显著更大的改善.
- 在实验组的鼻镜,VAS和RQLQ得分中观察到更强的改善,具有类似的安全概况.
结论:
- 结合鼻水和Aze-Flu鼻雾水,为管理中度至重度PAR提供了显著的额外好处.
- 这种组合疗法耐受性良好,并显示出良好的安全性.
- 研究结果表明,这种方法对于初级保健机构来说是一个有价值的治疗选择.
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