在接受18F-FDG PET/CT的肺癌患者中,快食葡萄糖的升高是常见的:简要报告
Bojan Bojanic1,2, Moritz Schwyzer3,4, Thomas Sartoretti1,2
1Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland.
Metabolism open
|October 29, 2025
概括
在接受PET/CT扫描的肺癌患者中,超过一半的患者表现出不正常的禁食葡萄糖水平. 这凸显了在这个患者群体中更好的查和高血糖管理策略的需要.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 医疗成像医学成像
背景情况:
- 肺癌患者经常接受氧葡萄糖正子发射断层扫描/计算机断层扫描 (FDG PET/CT) 成像.
- 在FDG PET/CT之前评估了毛细血管禁食血糖 (cFBG),但这个人群中的血糖概况没有很好的特征.
- 较高的葡萄糖水平可能会影响FDG的吸收,可能会影响PET/CT的解释.
研究的目的:
- 在FDG PET/CT之前,对肺癌患者的血糖概况进行表征.
- 为了确定这个队列中异常的禁食葡萄糖水平的患病率.
- 探索与高cFBG水平相关的因素.
主要方法:
- 研究了一组240名计划接受FDG PET/CT的肺癌患者.
- 用美国糖尿病协会的指导方针测量和分类了毛细血管禁食血糖 (cFBG).
- 用多变量线性回归分析来确定cFBG水平的独立预测因素.
主要成果:
- 中位数cFBG为104 mg/dL,其中63%的患者表现出非正常水平 (≥100 mg/dL).
- 即使不包括已知的糖尿病患者,60%的人有非正常的cFBG,8%的人符合未诊断糖尿病的标准.
- 传统的风险因素,如BMI和身体脂肪组成,与CFBG水平没有独立相关.
结论:
- 在FDG PET/CT之前,相当一部分肺癌患者出现过高血糖症.
- 即使没有已知的糖尿病或传统风险因素,也存在异常葡萄糖水平.
- 这些发现强调了加强肺癌患者血糖失调的查和管理的必要性.
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