持续的丸激素抑制:在高级激素敏感前列腺癌的预后指标
Dongsheng Ma1,2, Tao Zhuo3, Xin Huang4
1Department of Reproductive Medicine, The Affiliated Bozhou Hospital of Anhui Medical University, Bozhou, China.
Frontiers in endocrinology
|October 29, 2025
概括
在高级激素敏感前列腺癌 (aHSPC) 患者中,持续的抑制显著改善了结果. 监测水平提供了一种可靠的方法来预测治疗疗效和患者预后.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
背景情况:
- 先进的激素敏感前列腺癌 (aHSPC) 需要有效的治疗策略.
- 安卓素剥夺疗法 (ADT) 是aHSPC的基石治疗,旨在抑制水平.
- 在HSPC中预测治疗反应和预后仍然是一个临床挑战.
研究的目的:
- 调查持续的抑制与aHSPC患者的临床结果之间的关系.
- 为了确定ADT期间的纵向丸激素监测是否可以预测瘤进展和预后.
主要方法:
- 对来自两个医疗中心的336名aHSPC患者的回顾性分析.
- 在ADT期间进行串行丸激素监测,分层分为持续和非持续丸激素反应组.
- 评估基线特征,进展时间 (TTP) 和生存结果.
主要成果:
- 持续抑制的患者的平均存活时间明显更长 (7.58年 vs 3.00年) 和TTP (23.7个月 vs 13.7个月).
- 在最低/平均丸激素水平和TTP之间发现了逆相关性.
- 内脏转移和高瘤负载预测丸激素稳定不良,而持续反应状态降低了死亡风险.
结论:
- 持续丸激素抑制是评估HSPC治疗疗效的临床适用方法.
- 在ADT期间监测丸激素水平可以有效预测HSPC患者的预后.
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