用于预防COG认知障碍 (T-COG试验) 的taxifolin:一种随机,双盲,安慰剂对照试验的研究方案
Tetsuya Chiba1, Yorito Hattori1,2, Koko Asakura3
1Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
Frontiers in nutrition
|October 29, 2025
概括
这项研究研究了flavonoid taxifolin,作为一种潜在的认知衰退治疗方法. 早期的发现表明,taxifolin可能会改善轻度损伤或痴呆症患者的认知功能.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 目前的抗β-粉样蛋白抗体在改善认知功能的有效性有限.
- 对于轻度认知障碍 (MCI) 和轻度痴呆症,需要具有神经保护作用的新疗法.
- 作为一种黄类物质的塔克西福林 (Taxifolin) 具有类神经保护作用,包括抗粉样蛋白和抗炎性质.
研究的目的:
- 评估taxifolin在改善MCI或轻度痴呆症患者的认知功能方面的疗效.
- 评估taxifolin对预防进一步认知衰退的影响.
- 为了研究taxifolin对大脑健康的神经成像标志物的影响.
主要方法:
- 一个随机,双盲,安慰剂控制,交叉试验 (T-COG试验) 涉及60名患者.
- 参与者每天服用100毫克口服的taxifolin或安慰剂,持续12周,随后进行6周的清洗期.
- 用蒙特利尔认知评估,阿尔茨海默病评估量表-认知子量表14和Trail Making Test来评估认知功能.
主要成果:
- 预先的观察数据表明,口服的taxifolin与MCI或轻度痴呆症患者的认知改善有关.
- 该T-COG试验旨在在严格的临床环境中证实这些发现.
- 在之前的研究中,taxifolin证明了粉样β聚合和寡合化的抑制,降低了海马神经炎症,并刺激了脑淋巴血管的形成.
结论:
- 由于其多目标神经保护作用,Taxifolin为认知障碍提供了一个有前途的治疗候选药物.
- 试验的结果可以支持taxifolin作为一种安全,廉价和有效的治疗选择.
- 需要进一步的研究来探索taxifolin在神经退行性疾病中的全部治疗潜力.
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