孤独对癌症死亡率的影响:系统性审查和元分析
Samantha Cheng1, Joshua Yi1, Keiran Pace1
1University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
BMJ oncology
|October 29, 2025
概括
孤独和社会隔离显著增加癌症患者的死亡风险. 这一系统性审查强调了在癌症护理中需要心理社会支持,以改善患者的生存率和结果.
科学领域:
- 在瘤学瘤学.
- 心理社会瘤学
- 流行病学 流行病学
背景情况:
- 孤独和社会隔离深深影响癌症患者的情感和心理福祉.
- 以前的研究表明,孤独与癌症预后/生存之间存在负相关性.
- 潜在的机制涉及生物学,心理和社会因素,包括治疗准入和免疫功能.
研究的目的:
- 进行首次关于癌症患者遭受孤独和社会隔离的死亡率的系统审查和元分析.
- 调查孤独/社会隔离与全因和癌症特异性死亡率之间的联系.
主要方法:
- 在MEDLINE,Embase和PsycINFO数据库中进行系统搜索,截至2024年9月13日.
- 包括16项研究 (13项在元分析中),平均样本大小为6248名患者 (平均年龄为63岁).
- 随机效应元分析,以评估孤独/社会隔离对死亡率的影响.
主要成果:
- 孤独和社会孤立与所有原因死亡率的增加有关 (HR 1.34;95% CI 1.26-1.42).
- 孤独/社会隔离与癌症特异性死亡率之间发现了显著的联系 (HR 1.11;95% CI 1.02-1.21).
- 常见的测量工具包括社交网络指数和UCLA孤独度量表.
结论:
- 孤独和社会孤立与癌症患者较高的全因和癌症特异性死亡率有关.
- 研究结果支持将心理社会评估和干预措施纳入癌症护理.
- 需要进一步的研究来证实这些关联,并指导临床实践的改进.
相关概念视频
01:21Cancer Survival Analysis
645
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
645
01:19Psychoneuroimmunology: Diabetes and Cancer
432
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
432
01:30Social Relationships and Well-Being
246
The significance of social relationships in psychological well-being is a well-established area of inquiry within social psychology. Research consistently demonstrates that the presence of meaningful, supportive relationships enhances emotional health, while the absence or deterioration of such connections can contribute to psychological distress. Relationships serve as a foundation for emotional support, identity, and social belonging, all of which are critical to an individual’s overall...
246
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:12Relationship Formation
45.2K
What do you think is the single most influential factor in determining with whom you become friends and whom you form romantic relationships? You might be surprised to learn that the answer is simple: the people with whom you have the most contact. This most important factor is proximity. You are more likely to be friends with people you have regular contact with. For example, there are decades of research that shows that you are more likely to become friends with people who live in your dorm,...
45.2K
02:20Longitudinal Research
13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K