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在多中心回顾性研究中,tNGS揭示了占主导地位的混合病毒感染

Xiaoqi Zhang¹, Rui Tang², Xiaoyan Li³

¹Department of Pulmonary and Critical Care Medicine, Second People's Hospital of Weifang, Weifang, 261041, People's Republic of China.

Infection and drug resistance

|October 29, 2025

概括

与传统方法相比,目标下一代测序 (tNGS) 提供了更全面的检测病毒,细菌和真菌共感染的呼吸道疾病. 这种先进的方法揭示了更广泛的病原体谱,有助于复杂的诊断.

科学领域:

医学诊断医学诊断医学诊断
传染性疾病传染性疾病
基因组学就是基因组学.

背景情况:

病毒性呼吸道感染会损害宿主免疫力,增加对二次细菌和真菌感染的易感性.
准确及时识别这些共同病原体是一个重大的临床挑战.
后COVID-19时代呈现复杂的呼吸道感染场景,需要先进的诊断工具.

研究的目的:

将目标下一代测序 (tNGS) 与用于识别病毒和混合呼吸道感染的传统方法的有效性进行比较.
评估tNGS在临床环境中的全面病原体检测能力.

主要方法:

以tNGS测试的834名患者和使用常规方法测试的2263名患者的回顾性分析.
两组之间的病原体概况的比较,包括病毒,细菌,真菌和非典型的微生物.

主要成果:

tNGS检测出明显更高比例的病毒共感染,细菌病原体 (例如,Klebsiella spp. ),真菌病原体 (例如,阿斯伯吉路斯种类). ) 和菌与传统方法相比.
由tNGS常识别的病毒包括爱斯坦-巴尔病毒,SARS-CoV-2和流感A病毒.
对Mycoplasma spp.,Mycobacterium tuberculosis和非结核菌的检测率与tNGS显著更高.

结论:

针对性下一代测序 (tNGS) 确定了更高的流行率和更广泛的病毒共感染和二次细菌/真菌感染.
在临床实践中,tNGS显示出作为复杂呼吸道感染的综合诊断方法的潜力.

关键词:

亚斯珀吉洛斯 (Aspergillus) 是一种植物.粘膜粘膜是一种粘膜.混合病毒感染混合病毒感染.在COVID-19后的时间里.tNGS是什么意思 tNGS是什么意思病毒病毒病毒病毒

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