病例报告:在一个患有全身性红斑狼的儿科患者中,化诱导的泛性性牛皮
Xue Wang1,2, Linlin Dong1,2, Hui Qiu1,2
1Department of Pediatric Nephrology and Rheumatism and Immunology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Frontiers in pediatrics
|October 29, 2025
概括
氧化 (HCQ) 很少会在成年人中引起泛性性牛皮 (GPP). 本报告详细介绍了HCQ在患有系统性红斑狼 (SLE) 的儿童中引发的第一例儿科GPP病例.
科学领域:
- 皮肤病学 皮肤病学
- 儿科风湿病学 儿科风湿病学
- 临床案例研究 临床案例研究
背景情况:
- 氧化 (HCQ) 是系统性红斑狼 (SLE) 的首要治疗方法.
- 罕见的HCQ不良影响,如泛性性牛皮 (GPP),主要记录在成年人群中.
- 在儿科SLE患者中HCQ诱导的GPP的发生仍然未经记录.
研究的目的:
- 报告第一个被记录的一般性性牛皮病 (GPP) 病例,该病例是由氧化 (HCQ) 诱导的,该病例发生在被诊断为全身性红斑狼 (SLE) 的儿科患者身上.
- 突出HCQ作为儿童SLE病例中GPP触发者的潜力.
- 强调迅速停止HCQ的重要性,以管理这种罕见的不良事件.
主要方法:
- 一个详细的临床案例介绍,一个7岁的女性SLE患者在开始HCQ治疗后出现了不良反应.
- 皮肤病变的组织病理学检查,以确认GPP的诊断.
- 治疗方案的记录和 HCQ 停用后患者的反应.
主要成果:
- 儿科患者发烧,肝功能障碍,并在HCQ启动后三周传播了.
- 组织病理学证实了GPP特征,包括表皮变化和炎症细胞透.
- 在HCQ戒断和支持性治疗 (甲基普雷迪尼索隆,IVIG,抗生素,肝保护剂) 之后,患者在9天内表现出显著的临床改善,瘤消失和炎症标志物的正常化.
结论:
- 氧化 (HCQ) 应被认为是全身性红斑狼 (SLE) 的儿科患者普遍性性牛皮 (GPP) 的潜在触发因素.
- 在这种情况下,立即停止HCQ治疗对于实现最佳结果至关重要.
- 病变发生可能涉及Interleukin-17和Interleukin-36细胞因子通路的协同作用,这表明未来治疗的潜在点.
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