预防性静脉注射富罗塞米德用于降低单极性泌尿外前列腺手术中低血风险:一项随机临床试验
Farshad Gholipour1, Hossein Bahrami Samani1, Alireza Assadi2
1Department of Urology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Iranian journal of medical sciences
|October 29, 2025
概括
预防性furosemide显著减少低血症和TUR综合征在单极横尿切除前列腺 (TURP). 然而,它可能会导致低血,需要对患者进行仔细评估以确保安全使用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 手术并发症 手术并发症
- 临床试验 临床试验
背景情况:
- 通过尿道切除前列腺 (TURP) 是良性前列腺增生 (BPH) 的标准.
- 单极TURP可能导致TUR综合征,包括低血和流体过载.
- 这项研究调查了furosemide对这些并发症的预防作用.
研究的目的:
- 评估预防性furosemide在单极TURP期间预防低血和TUR综合征的疗效.
- 评估罗西米德对血清,水平和液体平衡的影响.
- 为了确定与furosemide使用相关的并发症率和恢复时间.
主要方法:
- 三重盲点随机临床试验,涉及接受单极TURP的患者.
- 患者被分为洛塞米德和对照组.
- 主要结局:血清的变化和低血的发生率;次要结局:液体平衡,并发症,恢复.
主要成果:
- 罗塞米德组的低血症发病率显著降低 (P=0.008).
- 手术后血清水平在罗塞米德组较高 (P=0.011),而水平较低 (P=0.003).
- 发生了轻度,可控的低血,特别是在基线<4.1 mmol/L的患者中.
结论:
- 在手术前,罗西米德有效地降低了单极TURP期间的TUR综合征风险和低血症.
- 富罗塞米德的效用受到潜在的低血的限制,需要对患者进行特定的评估.
- 在这种情况下,需要进行进一步的研究,以便在这种情况下最佳和安全地使用罗塞米德.
更多相关视频
05:32Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection
Published on: September 21, 2015
33.6K
07:59Bedside Ultrasound for Guiding Fluid Removal in Patients with Pulmonary Edema: The Reverse-FALLS Protocol
Published on: July 28, 2018
11.7K
相关概念视频
01:25Urinary Tract Calculi VI: Surgical Management
366
Procedures for Kidney StonesMedical intervention is necessary when kidney stones or renal calculi are too large to pass spontaneously (typically greater than 5 millimeters) when stones are accompanied by symptomatic infection (such as fever or pyelonephritis), when they impair kidney function, or when they cause persistent symptoms like severe pain, nausea, or urinary retention. Additionally, patients with only one kidney or those who cannot be treated with medical management also require...
366
01:30Urinary Tract Calculi III: Medical Management
191
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
191
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
246
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
246
01:28Antihypertensive Drugs: Potassium-Sparing Diuretics
2.2K
Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
2.2K
01:22Imaging Studies V: Intravenous Urography and Retrograde Pyelography
1.0K
IntroductionIntravenous Urography (IVU) and Retrograde Pyelography (RP) are important diagnostic imaging techniques used to evaluate the urinary system. These methods help identify structural abnormalities, obstructions, and functional issues in the kidneys, ureters, and bladder. Both procedures use iodine-based contrast media to enhance the visibility of urinary tract structures on X-ray images, though they differ in their methods and indications.1. Intravenous Urography (IVU)Intravenous...
1.0K
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
256
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
256