通过集成的多omics探索血停综合征在缺血性心力衰竭中的分子特征和相互作用
Aolong Wang1,2,3, Jingjing Wei1,2, Lijie Qiao4
1Department of Cardiovascular Disease, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, China.
Frontiers in molecular biosciences
|October 29, 2025
概括
这项研究显示,在缺血性心力衰竭 (IHF) 的血静止综合征 (BSS) 中,免疫调节失调和凝血受损. 像F2,F8,F9和FN1这样的关键目标显示了BSS的IHF的诊断和治疗潜力.
科学领域:
- 心血管医学 心血管医学
- 综合医学是一个整体的医学.
- 系统生物学 系统生物学
背景情况:
- 缺血性心力衰竭 (IHF) 是一个主要的全球健康问题.
- 血停滞综合征 (BSS) 是传统中国医学中IHF的一个关键病理特征.
- 了解BSS在IHF中的分子机制对于开发有效的治疗方法至关重要.
研究的目的:
- 阐明IBF中BSS的生物特征和潜在机制.
- 为了确定核心分子网络和潜在的诊断/治疗目标,以 BSS 在 IHF.
- 整合多学科数据,以全面了解BSS病原性.
主要方法:
- 采用了一个综合的多omics战略:转录组学,蛋白组学和有针对性的代谢组学.
- 在IHF患者中分析了BSS的分子特征,并与临床参数相关联.
- 使用iPRM,RT-qPCR,ROC分析和药理干预验证了关键分子标.
主要成果:
- 鉴定了435种不同表达的基因,176种蛋白质和40种与IHF和BSS相关的代谢物.
- 突出了补充/凝血级联和B细胞受体信号通路的参与.
- 确定F2,F8,F9和FN1作为核心分子特征和IBF中BSS的潜在诊断/治疗点.
结论:
- 免疫失调,炎症和凝血受损是IBF中BSS的核心原因.
- 补体和凝血级联,以及B细胞受体信号传递,是关键的途径.
- 在IHF中,F2,F8,F9和FN1代表了诊断和治疗BSS的有希望的目标.
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