对结直肠癌进行治疗意图的手术患者的术后深静脉血栓形成:前性队列研究
Neerav D Aruldas1, Albert Kota2, Deepa R Korula3
1General and Colorectal Surgery, Christian Medical College Vellore, Vellore, IND.
Cureus
|October 29, 2025
概括
结直肠癌患者的术后深静脉血栓塞 (DVT) 可以通过在医院的低分子量肝素和压缩来预防. 这项研究在接受这种有限的血栓预防治疗的印度患者中没有发现DVT.
科学领域:
- 血管外科 血管外科
- 在瘤学瘤学.
- 血栓形成研究研究
背景情况:
- 深静脉血栓症 (DVT) 是一个重要的术后并发症,特别是在结直肠癌 (CRC) 患者中,由于长时间的手术,特定的定位,骨盆剖析和新辅助化学放射治疗.
- 目前的指导方针建议使用药理剂 (例如低分子量肝素) 和机械方法 (渐进式压缩 - GCS) 进行28天的术后血栓预防.
- 然而,许多患者只接受医院内血栓预防治疗,因此需要评估其在印度CRC患者群体中的有效性.
研究的目的:
- 估计印度患者进行结直肠癌治疗性意图手术的DVT的频率.
- 评估使用低分子量肝素 (LMWH) 和GCS进行医院内血栓预防的有效性,以预防手术后 DVT.
主要方法:
- 接受治疗性结直肠癌手术的患者通过双重超声检查进行了手术前的DVT查.
- 所有参与者都接受了医院内用LMWH和GCS进行血栓预防.
- 随访包括手术后28天至6个月的症状和无症状DVT的查,使用多普勒超声波或电话症状监测.
主要成果:
- 在招募的42名患者中,有13人接受了多普勒超声波随访,29人通过电话监测.
- 在随访期间没有检测到无症状或有症状的DVT.
- 两组之间没有观察到风险因素的显著差异,除了多普勒超声波组中对新辅助/辅助疗法的更大暴露.
结论:
- 用LMWH和GCS进行医院内血栓预防似乎足以预防印度结直肠癌患者进行治疗意图手术后的症状和无症状DVT.
- 需要更大的样本大小才能在印度的这个患者群体中最终推这种方法用于血栓预防.
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