通过3D打印进行自我乳化药物输送系统 (SEDDS) 的结构化工程:3D打印:综合性审查
Induja Govindan1, Anjana A Kailas1, K A Abutwaibe1
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal 576104, India.
International journal of pharmaceutics: X
|October 29, 2025
概括
将自乳化药物输送系统 (SEDDS) 与3D打印 (3DP) 结合起来,可以提供个性化医疗. 本综述探讨了SEDDS的3DP技术,强调了未来制药开发的好处和挑战.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 3D打印应用 3D打印应用
背景情况:
- 自乳化药物递送系统 (SEDDS) 提高了药物的溶解性和生物可用性.
- 传统的SEDDS制造面临着可扩展性和剂量统一性的挑战.
- 个性化医疗需要先进的剂量形式技术,以进行量身定制的治疗.
研究的目的:
- 审查3D打印 (3DP) 技术在制定和生产SEDDS中的应用.
- 评估SEDDS的化沉积建模 (FDM),半固体挤出 (SSE) 和按需下降 (DoD).
- 在SEDDS开发中确定3DP的好处,局限性和未来前景.
主要方法:
- 审查用于SEDDS制定的现代3DP技术 (FDM,SSE,DoD).
- 对配方兼容性和操作机制进行批判性评估.
- 通过3DP分析制造业的挑战和SEDDS的潜在解决方案.
主要成果:
- 3DP为SEDDS提供了对剂型架构和药物释放动态的精确控制.
- FDM,SSE和DoD显示出SEDDS生产的潜力,每个都有独特的优势.
- 关键的限制包括材料限制,印刷品质的变化和监管障碍.
结论:
- 将3DP与SEDDS集成为个性化剂型提供了一个有前途的战略.
- 解决技术和监管障碍对于广泛采用至关重要.
- 未来的研究应该专注于优化3DP流程,以实现先进的SEDDS配方.
相关概念视频
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:27Drug Delivery Systems: Different Types
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
01:19Modified-Release Drug Delivery Systems: Overview
Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:23Oral Drug Delivery Systems: Introduction
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.