使用疾病-死亡多状态模型调查艾滋病毒疾病进展的危险因素
Roghayyeh Hassanzadeh1,2, Hossein Mahjub1,3, Mohammad Mirzaei4
1Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Journal of research in health sciences
|October 29, 2025
概括
抗逆转录病毒疗法 (ART) 减缓人类免疫缺陷病毒 (HIV) 进展到获得性免疫缺陷综合征 (AIDS) 和死亡. 诸如老年和结核病 (TB) 等危险因素增加了病情的进展,而ART和及时治疗降低了死亡率.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
背景情况:
- 人类免疫缺陷病毒 (HIV) 疾病的进展在个体之间有很大差异.
- 中间事件可以影响艾滋病毒患者的疾病进展和死亡率.
- 了解风险因素对于管理艾滋病毒/艾滋病的结果至关重要.
研究的目的:
- 研究各种风险因素对艾滋病毒疾病进展的影响.
- 分析中间事件对疾病轨迹的影响.
- 为全面的风险因素评估应用多州模型.
主要方法:
- 对673名成年患者 (1997-2023) 的回顾性队列研究.
- 利用一个多州框架,包括艾滋病毒感染者,获得性免疫缺陷综合征 (艾滋病) 和死亡状态.
- 应用疾病死亡多状态模型来评估风险因素对过渡的影响.
主要成果:
- 抗逆转录病毒疗法 (ART) 降低了艾滋病毒转化为艾滋病的风险.
- 高龄,结核病 (TB) 联合感染和特定的治疗指南增加了艾滋病毒转移到艾滋病的风险.
- 低教育程度,年龄较大,不保护性传播增加了艾滋病毒的死亡风险;ART和特定指南降低了它.
- 治疗,就业和先前监禁降低了艾滋病致死风险;结核病共感染增加了它.
结论:
- 早期诊断和及时的ART对于减少艾滋病的进展至关重要.
- 坚持治疗和结核病查/治疗非常重要,尤其对年轻人来说.
- 战略干预可以减轻艾滋病毒疾病的进展和死亡率.
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