目前的诊断方法用于重症患者的真菌感染
Alfredo Maldonado-Barrueco1, Inmaculada Quiles-Melero1, Julio García-Rodríguez2
1Clinical Microbiology and Parasitology Department. Hospital Universitario La Paz. Madrid, Spain.
概括
侵入性真菌感染对重症患者构成重大风险. 结合诊断方法可以改善检测,并指导及时的抗真菌治疗,以获得更好的结果.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
背景情况:
- 侵入性真菌感染 (IFI) 是重症患者的主要死亡原因.
- 全球IFI的发病率和物种多样性正在增加,特别是在SARS-CoV-2大流行后.
- 准确诊断IFI是具有挑战性的,但对于患者管理至关重要.
研究的目的:
- 对重症患者的侵入性真菌感染的当前诊断策略进行审查.
- 强调基于患者因素和真菌物种的量身定制诊断方法的重要性.
- 强调结合各种诊断方式的好处,以提高灵敏度和特异性.
主要方法:
- 复习经典的诊断方法 (显微镜,培养).
- 非经典诊断工具的评估,包括生物标志物 (1,3-β-D-葡萄糖,银河,曼南) 和分子测试.
- 讨论针对候群病原体的特定诊断策略,阿斯伯吉洛斯病,肺细胞病和粘膜病.
主要成果:
- 结合诊断测试可以提高FI的灵敏度和负预测值.
- 考虑到宿主风险因素,流行病学和样本类型的定制策略至关重要.
- 综合诊断方法优于单一测试方法.
结论:
- 综合性,病原体特定的诊断方法对于改善FI的重症患者的治疗结果至关重要.
- 及时和准确的诊断有助于迅速启动适当的抗真菌疗法.
- 需要对新型生物标志物和分子技术的持续研究,以进一步提高IFI诊断.
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