先进的父亲年龄影响精子和胎盘的共同位置DNA甲基组
Julia Barnwell1,2, Sophia Rahimi1,3, Sherri Lee Jones4
1Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Andrology
|October 29, 2025
概括
先进的父亲年龄与胎盘中DNA甲基化的改变有关,可能会影响后代的神经发育. 胎盘DNA甲基化可能作为父亲年龄对儿童发育影响的标记.
科学领域:
- 生殖生物学 生殖生物学
- 发育生物学是发展生物学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 流行病学研究将晚年父亲的年龄与后代神经发育障碍风险增加联系在一起,例如自闭症谱系障碍.
- 老年男性精子中DNA甲基化的改变可能会影响胎儿大脑发育和后来的童年行为.
研究的目的:
- 为了研究晚年父亲年龄与人类胎盘中DNA甲基化变化之间的关联.
- 为了将胎盘甲基化发现与以前的精子甲基化数据进行比较.
主要方法:
- 来自设计,开发和发现 (3D) 潜在出生队伍的64个胎盘样本的分析.
- 使用Illumina 850K阵列对胎盘DNA甲基化质疑.
- 使用名义p值<0.05.05,识别与基因相关的差异甲基化区域 (DMR).
主要成果:
- 先进的父亲年龄与688个胎盘基因的DNA甲基化变化相关,主要是低甲基化 (65%),包括8个印记的位置.
- 与父亲年龄相关的胎盘和精子甲基化变化之间观察到一个小的重叠 (7%).
- 七个常见的基因以前与自闭症谱系障碍易感性有关.
- 在与神经发育相关的基因 (GRM7,EBF3,FOXG1) 中观察到性别特异性的高甲基化.
结论:
- 先进的父亲年龄与人类胎盘中特定的DNA甲基化变化有关,特别是影响神经发育基因.
- 胎盘DNA甲基组可以作为代孕标志物,用于预测晚年父亲对孩子的潜在影响.
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