打破早产的循环:对母亲的压力和经常性早产的前性队列研究
Maayan Hagbi Bal1, Shimrit Yaniv Salem2, Eyal Sheiner2
1Department of Epidemiology, Biostatistics and Community Health Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
BJOG : an international journal of obstetrics and gynaecology
|October 29, 2025
概括
在怀孕期间持续的高感知压力显著增加了重复早产 (rPTB) 的风险. 这种压力,特别是在怀孕晚期,是不利于分娩结果的关键因素.
科学领域:
- 生殖健康 生殖健康
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 心理神经内分泌学心理学
背景情况:
- 复发性早产 (rPTB) 仍然是产科的一个重大挑战,影响新生儿的结果.
- 了解孕产妇压力及其生理标志物的作用对于预防策略至关重要.
研究的目的:
- 调查产前母亲感知到的压力,唾液皮质醇水平和经历重复早产 (rPTB) 的可能性之间的联系.
主要方法:
- 一项前性队列研究,涉及245名有自发单体早产 (PTB) 病史的妇女.
- 在怀孕期间,两次采集唾液样本和压力调查问卷.
- 多变量逻辑回归分析了基于高与低感知压力和皮质醇水平的rPTB的几率.
主要成果:
- 在怀孕后期,高感知压力与较高的RPTB发病率 (38.9%与19.2%) 有显著的关联.
- 持续高压力和怀孕后期高压力被确定为RPTB (adj. 分别为3.82和3.18的OR).
- 在唾液皮质醇水平,第一季度压力和rPTB之间没有发现任何关联.
结论:
- 持续性和晚期怀孕的高感知压力是重复过早分娩的重要风险因素.
- 这些发现强调了监测和管理孕妇在怀孕期间的压力的重要性,以潜在地减少rPTB的发生率.
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