在急性胰腺炎的小鼠模型中,通过基饮料调节肠道微生物群
Diego Aguirre-Ramírez1,2,3, María Garrido2, Lourdes Sánchez2,4
1Departamento De Farmacología, Fisiología y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Zaragoza, Zaragoza, Spain.
Molecular nutrition & food research
|October 29, 2025
概括
凯菲尔,特别是来自巴氏杀菌全脂牛奶 (PMK),可以帮助恢复急性胰腺炎 (AP) 破坏的肠道微生物群平衡. 在小鼠中,PMK和乳清克菲尔 (WK) 都显示出促进肠道健康和有益细菌的潜力.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 急性胰腺炎 (AP) 显著改变了肠道微生物群,导致了失活性.
- 恢复肠道微生物平衡对于管理AP和促进整体肠道健康至关重要.
研究的目的:
- 在小鼠模型中,研究巴氏化全乳 (PMK) 和乳清 (WK) 对AP诱导的肠道微生物群失调的作用.
- 评估作为一种功能性食品的潜力,以减轻与AP相关的肠道健康问题.
主要方法:
- 雄性BALB/cJRj小鼠被分为控制,AP诱导,PMK,WK,PMK+AP和WK+AP组.
- 用16S rRNA测序分析便样本,以描述肠道微生物群的组成.
- 途径分析被用来了解开治疗的功能影响.
主要成果:
- AP诱导导致了失生症,增加了像Marinifilaceae和Tannerellaceae这样的特定细菌家族.
- 在AP小鼠中,PMK治疗减少了有害细菌,增加了有益的,抗炎和产生酸盐的细菌.
- 在健康小鼠中,PMK和WK都调节了肠道微生物群,促进了短链脂肪酸 (SCFA) 生产并影响了代谢途径.
结论:
- 乳制品基的,特别是PMK,有效地抵消了由AP引起的肠道微生物群失衡.
- 凯菲尔证明了在AP环境中作为预防性和治疗性肠道健康支持的功能性食品的潜力.
更多相关视频
07:10Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
4.9K
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
1.2K
相关概念视频
01:27Microbiota of the Stomach and Small Intestine
The human gastrointestinal (GI) tract is characterized by distinct physicochemical conditions that shape its microbial communities. Among these, the stomach presents a particularly challenging environment for microbial colonization due to its highly acidic pH, ranging from 1 to 3. This extreme acidity effectively limits microbial density. However, certain acid-tolerant microorganisms are capable of surviving in this niche. Notably, Helicobacter pylori can colonize the gastric mucosa,...
01:21Acute Pancreatitis II: Pathophysiology
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...