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怀孕期糖尿病的母亲所生子女的眼睛微血管变化:南京眼睛研究

Shiya Shen¹, Xiaoqi Zhu¹, Wen Chen²

¹Department of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Translational vision science & technology

|October 29, 2025

概括

孕期糖尿病 (GDM) 的母亲生下的孩子表现出改变的眼睛微血管结构. 暴露于GDM与增加深血管复合体血管密度和减少后代的choriocapillaris perfusion有关.

科学领域:

眼科医生眼科眼科
儿科儿科儿科
血管生物学血管生物学

背景情况:

孕期糖尿病 (GDM) 是一个影响母亲和胎儿健康的日益严重的问题.
长期影响GDM对后代的眼部发育并未完全理解.
眼部微血管在视觉功能和发育中起着至关重要的作用.

研究的目的:

调查与未暴露对照组相比,暴露于母亲GDM的儿童的斑点视网膜和胆囊细胞 (CC) 的微血管差异.
评估GDM对后代眼血管系统的潜在长期影响.

主要方法:

一项以人口为基础的横截面研究 (南京眼睛研究) 涉及7岁儿童.
使用光学连贯断层扫描血管学 (OCTA) 评估了眼部微血管.
用了通用线性模型来分析母亲GDM和OCTA参数之间的关联,并对混因素进行调整.

主要成果:

暴露于母体GDM的后代在状象限深血管复合体 (DVC) 中显著增加了血管密度 (VD).
暴露于GDM的儿童显示CC流空隙的尺寸和面积更大,这表明choriocapillaris perfusion减少.
在表面血管复合体VD,状血管区域,斑点厚度或状状厚度中没有发现显著差异.

结论:

孕产妇GDM暴露与下降的choriocapillaris perfusion和增加后代的DVC血管密度有关.
这些发现表明GDM对儿童眼部微血管系统的潜在影响.
需要更加关注GDM后代的眼睛发育.

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