在COVID-19后的定量嗅觉功能障碍和帕洛斯米亚:观察性队列研究
Ditte Gertz Mogensen1, Rikke Kart Jacobsen2, Vibeke Backer1,3
1Department of Otorhinolaryngology, Head and Neck Surgery & Audiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
The Laryngoscope
|October 29, 2025
概括
后COVID嗅觉功能障碍 (OD) 往往包括帕洛斯米亚,这与更好的嗅觉功能有关. 患有定量OD的患者报告生活质量最低,持久性帕洛斯米亚显示出改善的潜力.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 嗅觉功能障碍 (OD) 是一种流行COVID-19后的疾病,其长期结果尚不清楚.
- 嗅觉扭曲 (parosmia) 是C19OD的一个常见表现.
研究的目的:
- 描述COVID-19后的OD (C19OD) 中的患者特征.
- 确定影响瘤持续性的因素.
- 研究帕洛斯米亚对定量嗅觉功能的影响.
主要方法:
- 在190名C19OD患者的纵向队列研究中.
- 使用"嗅棒"TDI测试评估的定量嗅觉功能.
- 帕洛斯米亚,主观功能和生活质量 (QoL) 在24个月内进行了评估.
主要成果:
- 帕洛斯米亚影响了73.7%的患者,并与较高的TDI得分相关 (p=0.001).
- 有量化OD的患者报告的QoL比单独有paroosmia的患者更差 (p=0.008).
- 持久性帕洛斯米亚显示TDI得分改善的趋势,没有预测基线特征.
结论:
- 帕洛斯米亚在C19OD中很常见,与更好的定量嗅觉功能相关.
- 量化OD显著影响QoL负面.
- 帕洛斯米亚持续性是无法预测的基线因素,但可能会随着时间的推移而改善.
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