阻塞性睡眠呼吸暂停和静脉血栓栓塞的风险:一个全国性的基于人口的研究
So Yeon Kim1, Yong Jin Shim2, Jaeyoung Cho3,4
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Sleep
|October 29, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 显著增加了静脉血栓塞栓症 (VTE) 的风险,包括肺栓塞和深静脉血栓症. 这项大规模的研究证实了OSA作为这些严重疾病的独立风险因素.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一个已知的心血管风险因素.
- 由于先前的研究中对混因子的调整有限,OSA和静脉血栓栓塞 (VTE) 之间的关联需要进一步澄清.
- 了解这种联系对于在OSA患者中管理心血管和前血栓风险至关重要.
研究的目的:
- 评估在被诊断患有OSA的患者中,VTE的发生率和风险,包括肺栓塞 (PE) 和深静脉血栓塞 (DVT).
- 调查OSA和VTE发展之间的独立关联.
- 在大型OSA队列中提供关于VTE风险的可靠流行病学数据.
主要方法:
- 一项全国性的基于人口的队列研究,利用韩国国家医疗保险数据库.
- 新诊断OSA的成年人的倾向得分与没有睡眠呼吸暂停的对照进行了匹配 (1: 5).
- 考克斯的比例危险回归模型分析了VTE发病率和危险比率 (HRs).
主要成果:
- 与对照组相比,患有OSA的患者的VTE发病率 (287.5每10万人年) 高于对照组 (205.0每10万人年).
- OSA独立地与VTE (HR,1.68) 的风险增加有关,包括PE (HR,1.82) 和DVT (HR,1.54).
- 结果在各个子组和敏感性分析中一致,证实了关联的稳定性.
结论:
- 阻塞性睡眠呼吸暂停是静脉血栓栓塞的独立危险因素.
- 这项研究证实了OSA与增加PE和DVT风险之间的显著关联.
- 这些发现强调了在OSA管理中考虑VTE风险的重要性.
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