饮食中的安托西亚尼丁皮拉戈尼丁激活了G蛋白结合受体35
Fumie Nakashima1, Sayako Shimomura1, Mayuka Wakabayashi1
1Graduate School of Bioagricultural Sciences, Nagoya University, Japan.
The FEBS journal
|October 29, 2025
概括
作为一种来自食物的化合物,佩拉戈尼丁激活了G蛋白结合受体35 (GPR35),这表明饮食中的安托西亚尼丁在GPR35信号传递和潜在的化疗预防中起着作用.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- G蛋白结合受体 (GPCR) 是关键的细胞表面受体,调节生理事件,是治疗点.
- G蛋白结合受体35 (GPR35) 在抗氧化,抗癌和抗炎功能中起作用.
- 对食物中产生的GPR35激动剂的理解是有限的.
研究的目的:
- 为了识别G蛋白结合受体35 (GPR35) 的新型食物衍生性激动剂.
- 阐明由食物衍生化合物激活GPR35的分子机制.
- 为了探索GPR35激动剂的抗炎潜力.
主要方法:
- 使用转化生长因子α (TGFα) 脱落试验对28种食植物化学物质进行查,以检测GPR35的激活.
- 评估3 - 氨酸酸的激动性活动,重点关注pelargonidin.
- 进行突变研究以确定GPR35激活的关键相互作用.
- 评估pelargonidin对Caco-2细胞中白蛋白-8的产生的影响.
主要成果:
- 佩拉戈尼丁被确定为一种强大的食物衍生的GPR35激动剂.
- 发现特定的相互作用,包括键和疏水性相互作用,对于pelargonidin-GPR35结合至关重要.
- 佩拉戈尼丁通过Caco-2细胞的GPR35激活来抑制促炎性细胞因特鲁金-8的产生.
结论:
- G蛋白结合受体35 (GPR35) 可能充当饮食中安托西亚尼丁的受体,如pelargonidin.
- 佩拉戈尼丁的抗炎作用是通过GPR35激活进行的.
- 这些发现提供了关于安东基亚尼丁的化学预防潜力及其分子机制的见解.
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