通过分子和血清检测确认的无症状人类感染禽流感A ((H5N1) 病毒:范围审查
Fatimah S Dawood1, Shikha Garg1, Pragna Patel1
12024 Influenza A(H5N1) Response, Centers for Disease Control and Prevention, Atlanta, Georgia.
JAMA network open
|October 29, 2025
概括
人类无症状禽流感A ((H5N1) 病毒感染很少见,通常通过对暴露个体的监测来检测. 进一步收集数据对于公共卫生风险评估和预防策略至关重要.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 高致病性禽流感A ((H5N1) 病毒对全球健康构成威胁,自1997年以来已报告了1000多例人类感染.
- 目前正在发生的动物疫情需要了解人类的甲型H5N1传播动态,包括无症状病例.
研究的目的:
- 在人类中识别和描述报告的无症状A(H5N1) 病毒感染病例.
- 包括通过分子和血清学测试 (MSC) 或单独分子测试 (MC) 确认的病例.
主要方法:
- 在多个数据库中进行了系统的文献搜索,截至2025年8月25日.
- 如果报告了符合MSC或MC标准的确诊A(H5N1) 感染,并以英语出版,则将研究纳入.
- 仅仅报告血清学测试或血清调查的文章被排除在外.
主要成果:
- 十项研究符合纳入标准,详细介绍了2个分子和血清学确认 (MSC) 病例和16个分子确认 (MC) 病例.
- 通过家庭接触调查确定了MSC病例;一个涉及家禽暴露,另一个建议人与人之间的传播.
- 主要通过加强对禽类暴露个体的监测和家庭接触调查来确定MC病例.
结论:
- 很少有人报告人类无症状的A(H5N1) 病毒感染.
- 大多数确诊的无症状病例是由于暴露个体的加强监测或接触追踪导致的.
- 需要关于无症状A ((H5N1) 感染的可靠数据来完善公共卫生应对措施.
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