精神分裂症,双极性或严重抑郁症以及COVID-19的后急性后果
Veer Vekaria1, Rohith Kumar Thiruvalluru1, Zoe Verzani1
1Weill Cornell Medicine, New York, New York.
JAMA network open
|October 29, 2025
概括
患有严重精神疾病 (SMI) 的个人在COVID-19感染后面临更高的SARS-CoV-2 (PASC) 后急性病变的风险. 协调的心理健康和COVID-19护理策略对于这个弱势群体至关重要.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 心理健康研究 心理健康研究
背景情况:
- 患有严重精神疾病 (SMI) 的人对COVID-19的脆弱性增加了.
- 在SMI患者中发展SARS-CoV-2 (PASC) 后急性继发症的风险尚不清楚.
- 了解这种关联对于开发有针对性的二次预防工作至关重要.
研究的目的:
- 为了确定被诊断为SMI的患者PASC发展的风险.
- 为了确定与SMI人口中PASC风险增加相关的因素.
主要方法:
- 从2020年3月到2023年4月,使用大规模电子健康记录 (EHR) 进行纵向队列研究.
- 纳入标准:年龄在21岁以上的成年人,已确认COVID-19感染,且已有SMI诊断 (精神分裂症,双相情感障碍或严重抑郁症).
- 在感染后30至180天评估PASC症状,结果根据人口统计和临床变量进行调整.
主要成果:
- 该研究包括1,625,857名COVID-19患者,其中15.9%的患者有SMI,24.8%的患者患有PASC.
- 患有SMI的患者显著增加了发展PASC的调整后几率 (OR,1.10;95% CI,1.08-1.11;P <.001).
- 年龄较大,非西班牙裔黑人和西班牙裔种族,更高的慢性疾病负担和COVID-19住院治疗与更高的PASC几率有关.
结论:
- 患有SMI的患者在COVID-19感染后患PASC的风险较高.
- 调查结果强调了综合护理策略的必要性,该策略既涉及心理健康,也涉及COVID-19管理.
- 需要进一步的研究和量身定制的干预措施,以减轻SMI患者的PASC风险.
更多相关视频
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
1.2K
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
23.3K
相关概念视频
Bipolar Disorder
584
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
584
Psychosis and Antipsychotic Drugs: Overview
770
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
770
Schizophrenia
670
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
670
Personality Disorders: Paranoid and Schizoid
474
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
Paranoid Personality Disorder
Paranoid personality disorder is...
474
Depression: Overview
735
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
735
Psychosis: Goals of Pharmacotherapy
434
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
434
