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塞夫迪尼尔和塞法莱克辛的比较,作为皮叶龙炎或尿症的逐步治疗方法
Andrew R Miesner1, Jonathan R Hurdelbrink1, Sarah M Wall1
1Drake University College of Pharmacy and Health Sciences, Des Moines, IA, USA.
Journal of pharmacy practice
|October 29, 2025
概括
塞夫迪尼尔和塞法列辛在严重的尿路感染 (SUTI) 中显示出类似的治疗失败率. 然而,塞法莱克辛的使用与更多的无计划诊所或急诊访问有关.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 对标准抗生素的耐药性增加,需要在严重的尿路感染 (SUTI) 中使用类素.
- 有限的临床数据存在于选择口服头类药物作为SUTI静脉注射治疗后的降级治疗.
研究的目的:
- 为了比较口服塞法莱克辛和塞夫丁尼尔之间的治疗失败率.
- 评估口服头素作为严重尿路感染的逐步降低疗法.
主要方法:
- 在一年内,在三个医院进行了对sUTI患者的回顾性研究.
- 纳入标准:静脉注射抗生素超过24小时,然后服用口服塞法列辛或塞夫丁尼尔.
- 主要结局:死亡的组合,在30天内重新住院/对尿路感染的访问,在90天内住院或Clostridoides difficile感染.
主要成果:
- 分析了75例塞夫迪尼尔和135例塞法莱克辛病例;基线特征相似.
- 整体复合性失败率为谢夫迪尼尔的8%和塞法列辛的14.1% (P=0.193).
- 塞夫迪尼尔组因尿路感染而进行的非计划诊所或急诊次数显著减少 (0%对7.2%,P=0.028).
结论:
- 在sUTI治疗中, cefdinir和cephalexin之间整体治疗失败率没有显著差异.
- 塞法莱克辛的使用与更高的非计划性诊所或尿路感染紧急诊所的发病率有关.
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