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基于PROTAC的HDAC降解:针对性表观遗传疗法的范式转变

Ambati Himaja1,2, Debojyoti Halder1,2, Suvankar Banerjee3,4

  • 1Epigenetic Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad Campus, Shamirpet, Hyderabad, 500078, India.

ChemMedChem
|October 29, 2025
PubMed
概括

与传统的抑制剂不同,向蛋白解酶的嵌合体 (PROTACs) 提供了一种新的方法来降解向蛋白质. 在治疗癌症和表观遗传疾病方面,HDAC-PROTACs通过选择性降解激素脱乙酶 (HDACs) 有望.

关键词:
招募 E3 酶的方法在HDAC-PROTAC中使用.选择性的降解降解选择性的降解有针对性的蛋白质降解降解.三元复合形成的三元复合形成.乌比奎丁-蛋白酶体系统

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