相关实验视频

Updated: Jan 6, 2026

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Rapid In Vivo Assessment of Adjuvant's Cytotoxic T Lymphocytes Generation Capabilities for Vaccine Development

Published on: June 19, 2018

疫苗免疫性和反应性之间的关系:叙述性综述

Daniel J Gromer¹, Suha Kalash², Ralph Tanios²

¹Hope Clinic of the Emory Vaccine Center, Emory University, Decatur, GA 30030, USA; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, USA.

|October 29, 2025

概括

疫苗的副作用 (反应性) 与免疫反应强度 (免疫性) 有着轻微的联系,特别是在mRNA疫苗中. 需要进一步的研究来理解这种关系,以便更好地开发疫苗.

科学领域:

疫苗学疫苗学疫苗学
免疫学免疫学免疫学
生物医学科学生物医学科学

背景情况:

疫苗反应性和免疫性之间的联系至关重要,但未得到充分研究.
了解这种关系可以为疫苗开发和公众沟通提供信息.

研究的目的:

综合各种疫苗平台中疫苗反应性和免疫性之间的关系的证据.
确定影响这种关联的因素,并突出未来研究的领域.

主要方法:

现有文献的叙述性审查.
综合来自不同疫苗平台和病原体的数据.
分析系统和局部反应与免疫反应之间的关联.

主要成果:

系统反应性和幽默免疫性之间存在温和的积极关联,特别是在mRNA SARS-CoV-2疫苗中.
与系统反应相比,局部反应对免疫反应的预测能力较低.
年龄,性别和HLA等位基因等因素影响反应性和免疫反应.

结论:

需要协调的工具和改进的研究设计来澄清反应性-免疫性关系.
了解机制联系可以指导疫苗开发,临床试验终点和沟通策略.
进一步的研究对于揭示疫苗症状的生物学基础及其预测作用至关重要.

关键词:

免疫性免疫性免疫性传染性疾病传染性疾病反应性是反应性的.耐受性耐受性疫苗疫苗是一种疫苗.

更多相关视频

Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination

Author Spotlight: Development and Evaluation of a Cationic Nanoemulsion-Encapsulated Retinoic Acid System for Mucosal Vaccination

Published on: February 23, 2024

Intralymphatic Immunotherapy and Vaccination in Mice

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

相关概念视频

Vaccinations

Vaccinations

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

Immunological Memory

Immunological Memory

Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...

Cross-reactivity

Cross-reactivity

Affinity and Avidity

Affinity and Avidity

Active versus Passive Immunity

Active versus Passive Immunity

Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...