环境混合物的产前暴露与早产之间的关系中的种族差异
Michael S Bloom1, Meghana Varde1, Roy R Gerona2
1Department of Global and Community Health, College of Public Health George Mason University, 4400 University Dr., MS 5B7, Fairfax, VA, 22030, USA.
International journal of hygiene and environmental health
|October 29, 2025
概括
产前暴露于环境 (EPs) 混合物与黑人母亲的早产风险增加有关,而不是白人母亲. 单个EP显示了各种各样的关联,BP-3和triclosan是混合物的关键成分.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于环境 (EPs) 是一个越来越令人担忧的问题.
- 在种族/种族群体之间存在早产 (PTB) 风险的差异.
- 了解EP对PTB的影响差异至关重要.
研究的目的:
- 调查产前泌尿EP和PTB之间的关联.
- 检查非西班牙裔黑人 (NHB) 和非西班牙裔白人 (NHW) 母亲之间的这些关联的差异.
- 确定导致PTB风险的关键EP.
主要方法:
- 对153名NHW和139名NHB母亲进行前性研究.
- 在怀孕18-22周收集的尿样.
- 通过LC-MS/MS量化尿路EPs (类,类,三类,双类) 的量化.
- 使用贝叶斯核机器回归 (BKMR) 分析混合物效应和个人EP的后勤回归.
主要成果:
- 观察到EP混合物和PTB之间的非线性关联.
- 较高的PTB概率与NHB母亲的EP混合物的第60至80个百分点有关,而不是NHW母亲.
- 二-3 (BP-3) 和三三 (TCS) 是重要的混合物成分;BP-1和双S (BPS) 单独与较低的PTB概率有关.
结论:
- 对EP混合物的产前暴露与NHB母亲的PTB风险增加有关.
- 个别的EP可能对种族群体的PTB风险产生不同的影响.
- 需要进一步的研究来阐明机制,并告知有针对性的干预措施.
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