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Updated: Jan 13, 2026

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使用NMR光谱和AlphaFold建模,对抗CRISPR蛋白AcrIE5的结构和机制研究

Sung-Hyun Hong1, Iktae Kim1, Gyujin Lee2

  • 1Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, South Korea; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul, 08826, South Korea.

Biochemical and biophysical research communications
|October 29, 2025
PubMed
概括

抗CRISPR蛋白AcrIE5通过与级复合体结合来抑制I-E型CRISPR-Cas系统. 它的结构揭示了对相互作用至关重要的移动循环,可能与DNA结合竞争.

关键词:
在AcrIE5中使用.阿尔法折叠是什么意思阿尔法折叠反-克里斯普尔 (Anti-CRISPR) 是一个很好的方法.这就是CRISPR-Cas.蛋白质结构 蛋白质结构

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Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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