在非损伤性D/EE-SWAS中为儿科量身定制的修改IC-CoDE方法
Luca Andreoli1, Elisa Granocchio2, Davide Caputo3
1Department of Pediatric Neuroscience, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy; Department of Humanities and Life Sciences, University School for Advanced Studies IUSS, Pavia, Italy.
Epilepsy & behavior : E&B
|October 29, 2025
概括
在缓慢睡眠期间 (D/EE-SWAS) 患有非损伤性发育和/或脑病的儿童经常表现出多领域认知和行为障碍,特别是在注意力执行和语言功能方面. 早期发病与更严重的神经发育障碍和较差的长期结果有关.
科学领域:
- 儿科神经学 儿科神经学
- 神经心理学 神经心理学
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 发展性和/或性脑病变,在缓慢睡眠期间出现尖端波激活 (D/EE-SWAS) 是一种影响儿童的疾病.
- 描述认知和行为特征对于理解D/EE-SWAS至关重要.
- 需要采用多领域的方法来全面评估神经发育影响.
研究的目的:
- 描述非损伤性D/EE-SWAS儿童的认知和行为特征.
- 探索这些形状和临床特征/结果之间的关联.
- 通过修改的症认知障碍国际分类 (IC-CoDE) 模型来定义认知行为表型.
主要方法:
- 对28名患有D/EE-SWAS的儿科患者的回顾性分析.
- 标准化的神经心理学电池评估语言,视觉空间,注意力-执行,行为和运动领域.
- 基于神经心理障碍四级严重程度得分的探索性集群分析.
主要成果:
- 大多数患者 (75%) 呈现注意力执行缺陷,其次是语言缺陷 (61%).
- 多域功能障碍很常见,其中61%显示普遍性功能障碍.
- 出现了三种不同的特征:严重的普遍性障碍 (集群1),主导的执行行为缺陷 (集群2) 和选择性认知障碍 (集群3).
- 与其他集群相比,集群1的长期功能明显恶化,SWAS发病时间较早.
结论:
- 一种结构化,多领域的神经心理学方法对D/EE-SWAS具有临床相关性.
- 识别的认知行为现象类型具有预后价值.
- 较早的D/EE-SWAS发作可能与更严重的神经发育障碍相关.
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