坎比洛巴克特 (Campylobacter jejuni) 在重复挑战感染模型后,刺激了桃体中强大的细胞因子反应
Christina L Swaggerty1, Alejandra V Velilla2, Kenneth J Genovese1
1U.S. Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center, College Station, TX 77845 USA.
Poultry science
|October 29, 2025
概括
在中多次接触Campylobacter jejuni会刺激淋巴组织中的免疫反应,表明宿主将其视为病原体. 然而,尽管有这种免疫活动,仍然存在持久性感染.
科学领域:
- 兽医免疫学 兽医免疫学
- 食物传播的病原体
- 禽类的健康 禽类的健康
背景情况:
- 坎比洛巴克特 (Campylobacter jejuni) 是人类细菌性食物传播疾病的主要原因.
- 禽类被确定为坎皮洛巴克特的储存库,通常被认为是共生的,通过受污染的产品导致人类疾病.
研究的目的:
- 为了研究在Campylobacter jejuni.两剂量挑战后, brojler的免疫反应.
- 为了监测关键的炎症和调节性细胞因子和化学因子对C. jejuni暴露的反应的变化.
主要方法:
- 肉小接受了两次口服C. jejuni (1x10^3cfu/mL在2天,1x10^7cfu/mL在28天).
- 35天后采集了桃体,用于对细胞因子 (IL1β,IL6,IL10,IFNγ,TGFβ4) 和化学因子 (CXCL8) 的mRNA表达分析.
主要成果:
- 显著更高的IL1β,IL10,TGFβ4和CXCL8的mRNA表达 (2.6-5.8倍增加;P ≤0.04) 在桃体中观察到.
- 没有检测到IL6和IFNγmRNA表达的显著变化 (P>0.05).
结论:
- 重复暴露于C. jejuni会诱导肉桃体中强大的细胞因子和化学因子反应.
- 宿主将C. jejuni识别为病原体,从而产生免疫反应,但仍然存在持久的感染.
- 这突显了家禽库中复杂的宿主-病原体相互作用.
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