[更新:器官捐赠和保存] 器官捐赠和保存
Gyoergy Lang1,2, Christian Lang3
1Klinik für Thoraxchirurgie, UniversitätsSpital Zürich, Zürich, Schweiz.
Zentralblatt fur Chirurgie
|October 29, 2025
概括
器官捐献方面的创新,包括正常热的ex vivo肺 perfusion (EVLP) 和循环死亡后的捐献 (DCD),正在扩大捐赠者池并改善肺移植结果. 控制的低温保存也提高了后勤的灵活性.
科学领域:
- 心血管和肺部医学 心血管和肺部医学
- 移植生物学 移植生物学
- 手术创新 在外科创新.
背景情况:
- 肺移植面临着挑战,因为捐赠肺缺乏和保存限制.
- 器官保存和捐献策略的进步对于改善患者的治疗结果至关重要.
- 边缘捐赠肺和延长保存时间仍然是研究的重要领域.
研究的目的:
- 审查最近在器官捐献和捐赠者肺部保护方面的创新.
- 要突出正常热的ex vivo肺 perfusion (EVLP),循环死亡后的捐赠 (DCD) 和低温保存对肺移植的影响.
- 总结关于优化捐赠肺部利用率和活力的当前知识状态.
主要方法:
- 审查肺移植技术和策略的关键进展.
- 在捐赠肺的评估和康复中,分析常温活体肺 perfusion (EVLP) 的作用.
- 循环死亡 (DCD) 后捐献的检查协议和结果.
- 在10°C控制的低温保存以延长肺活力的评估.
主要成果:
- 常温活体肺 perfusion (EVLP) 允许使用高风险的供体肺部,改善移植结果.
- 循环死亡 (DCD) 后的捐献提供了与传统捐献相比较的替代方案,解决了供体短缺问题.
- 在10°C控制的低温保存延长了保存时间,并提供了更大的调度灵活性.
结论:
- EVLP,DCD和受控的低温保存在肺捐赠和保存方面取得了重大进展.
- 这些创新扩大了供体库,提高了肺移植的可行性和成功.
- 预计这些技术的未来研究和临床整合将进一步彻底改变肺移植标准.
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