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相关概念视频

Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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针对临床研究的患者数据采集:一项试点研究测试了两个平台.

Satoshi Shoji1, Lauren W Cohen2, Keith A Marsolo2

  • 1Duke Clinical Research Institute, Durham, NC, USA; Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Contemporary clinical trials
|October 29, 2025
PubMed
概括

通过应用程序编程接口 (API) 可以捕获患者导向的电子健康记录 (EHR) 数据,但记录请求的成功率很低. 为了更广泛的采用,需要改进工作流程和用户支持.

关键词:
应用程序编程接口 (API) 是一个应用程序编程接口.数据检索数据检索电子健康记录是电子健康记录.医疗记录请求 医疗记录请求以患者为导向的数据捕获.

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科学领域:

  • 医疗信息学 医疗信息学
  • 患者参与 患者参与
  • 电子健康记录电子健康记录

背景情况:

  • 以患者为导向的数据捕获允许个人访问和共享其电子健康记录 (EHR) 数据.
  • 这种方法可以提高患者参与度,减少数据碎片化.
  • 目前针对患者的数据采集方法的实际可行性和可靠性尚未得到充分理解.

研究的目的:

  • 评估不同针对患者的数据采集平台的可行性.
  • 为了比较基于API和记录请求方法在EHR数据检索中的有效性.

主要方法:

  • 一项试点研究涉及杜克医院34名心力衰竭患者.
  • 参与者使用了Hugo Health (基于API的检索) 和/或Datavant (记录请求).
  • 每个平台的可行性和数据检索成功被评估.

主要成果:

  • 通过API方法检索了88%的记录;记录请求检索了20%.
  • API捕获了外部术语,但错过了一些本地EHR诊断;记录请求有更高的数据遗漏.
  • 低意愿重新使用供应商 (22%) 和需要在线支持 (33%) 被观察到. 技术挑战包括JSON文件处理和手动PDF抽象.

结论:

  • 以患者为导向的数据采集在技术上是可能的,但依赖于方法的可变性很大.
  • 基于API的检索显示出高的成功率,而记录请求的成功率较低.
  • 改进的工作流程和用户支持对于患者导向的电子病历数据采集的广泛可行性至关重要.