在史蒂文斯-约翰逊综合征/癌症患者中有毒表皮解的眼部表现
Jin-Jhe Wang1, Chun-Bing Chen2, Eugene Yu-Chuan Kang3
1Department of Ophthalmology, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; Graduate Institute of Clinical Medicine, Chang Gung University, Taoyuan, Taiwan.
The ocular surface
|October 29, 2025
概括
患有史蒂文斯-约翰逊综合征/有毒表皮解 (SJS/TEN) 的癌症患者面临着显著的眼睛并发症,特别是那些接受免疫检查点抑制剂 (ICI) 治疗的患者. 早期的眼科干预和监测对于管理这种高风险群体的眼病发病率至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 皮肤病学 皮肤病学
背景情况:
- 史蒂文斯-约翰逊综合征/有毒表皮解体 (SJS/TEN) 可能导致严重的眼部并发症.
- 癌症患者是SJS/TEN的脆弱人群,免疫检查点抑制剂 (ICI) 可能会改变疾病特征.
研究的目的:
- 研究被诊断为SJS/TEN.EN的癌症患者的眼部参与,风险因素和结果.
- 具体评估ICI对眼部并发症的表现和严重性的影响.
主要方法:
- 一项回顾性病例控制研究包括了112名患有SJS/TEN.EN的癌症患者.
- 使用Sotozono的分类来评估眼部干扰,并通过后勤回归分析风险因素.
- 从2004年到2024年,数据是在一个机构收集的.
主要成果:
- 眼部并发症发生在41.1%的患者中,有毒表皮解 (TEN),全身粘膜干扰和多药性被确定为显著的危险因素.
- 与ICI相关的SJS/TEN显示出更长的潜伏时间和延迟愈合.
- 与ICI相关的SJS/TEN幸存者经历了更严重的慢性眼睛问题,包括更严重的干眼和较差的视力恢复.
结论:
- 在患有SJS/TEN的癌症患者中,眼部发病率很大,特别是那些接受ICI治疗的人.
- 这些发现强调了积极的眼科护理和持续监测ICI相关SJS/TEN患者的急需.
- 警的查和管理对于减轻长期视力障碍至关重要.
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