乳清蛋白水解纤维素-德克斯输送氧化铁:稳定性和生物可用性
Huanhuan Su1, Hao An1, Yun Zhai1
1School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, 310018, China.
International journal of biological macromolecules
|October 29, 2025
概括
一种新的乳清蛋白水解物纤维-德克斯 (WPHF-DEX) 复合物提供氧化铁,减少胃肠道副作用并改善铁的吸收. 与传统补充剂相比,这种创新系统可以提高铁的生物可用性.
科学领域:
- 生物材料科学 生物材料科学
- 营养生物化学 营养生物化学
- 药物输送系统 药物输送系统
背景情况:
- 缺铁性贫血 (IDA) 是一种普遍存在的全球营养障碍.
- 传统的铁补充剂会引起胃肠道的困扰,并且生物可用性差.
- 需要改进的铁输送系统,以提高效率和耐受性.
研究的目的:
- 设计和表征一种抗氧化乳清蛋白水解纤维素-德克斯 (WPHF-DEX) 复合物,用于输送氧化铁.
- 为了评估WPHF-DEX-氧化铁复合物的稳定性,生物相容性和铁的生物可用性.
- 评估该系统在克服传统铁补充剂的局限性方面的潜力.
主要方法:
- 通过铁氧化物在现场的共同沉合成WPHF-DEX复合物.
- 使用FTIR光谱学进行表征,以确认铁结合和复合稳定性.
- 在体外消化和基于细胞的测试以评估胃肠道刺激,铁氧化状态和细胞毒性.
- 铁的生物利用度与硫酸铁 (FeSO4) 的比较.
主要成果:
- 该WPHF-DEX复合体显著改善了抗氧化特性,并暴露了更多的铁结合点.
- FTIR证实了WPHF-DEX和氧化铁之间的稳定协调纽带.
- 试验室消化显示胃粘膜刺激减少,并保持铁氧化状态.
- 在没有细胞毒性的情况下,WPHF-DEX-Fe复合体在体外显示铁的生物利用率是FeSO4的1.4倍.
结论:
- WPHF-DEX复合系统为开发具有低刺激性,高度生物相容性的氧化铁输送系统提供了一个有前途的方法.
- 这种新的系统增强了铁的生物可用性,克服了与传统铁补充剂相关的不良影响.
- WPHF-DEX-Fe复合体代表了治疗缺铁性贫血的潜在进展.
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