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Updated: Jan 13, 2026

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

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反4-基-3-尼托) 乙烯抗体的亲和力成熟的结构基础

Mutsumi Yoshida1, Yuya Hanazono2, Nobutaka Numoto2

  • 1Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, 1-5 Hangi-cho, Shimogamo, Sakyo-ku, Kyoto, Kyoto, 606-8522, Japan.

Archives of biochemistry and biophysics
|October 29, 2025
PubMed
概括

抗体亲和力成熟通过体质突变 (SHM) 增强了抗原结合. 对抗NP抗体的结构分析揭示了保存的识别点和突变驱动的微调,以改善蛋白质相互作用.

关键词:
亲密关系成熟期的到期.抗原结合 抗原结合规范性变化 规范性变化晶体结构 晶体结构热力学是一种热力学.

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