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西申药片通过基于转录组学分析的AGE/RAGE/NLRP3通路缓解了DSS诱导的大肠炎

Lan Ming¹, JiaMin Ji², ZhaoFeng Luo³

¹YanchengTCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu Province, 224000, China; Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210000, China.

Journal of ethnopharmacology

|October 29, 2025

概括

西申药 (SSP) 通过减少炎症和恢复肠道屏障功能,有效治疗性结肠炎 (UC). 这种传统疗法通过抑制AGE-RAGE-NLRP3信号通路而起作用,为UC患者提供了一种新的治疗方法.

科学领域:

药理学药理学是指药理学的学科.
免疫学免疫学免疫学
胃肠病学胃肠病学

背景情况:

性结肠炎 (UC) 是一种具有重大患者影响的慢性炎症性结肠疾病.
西申药 (SSP) 是一种传统的中医药,在胃肠道问题上有着悠久的使用历史,但其在UC中的机制尚不清楚.

研究的目的:

在性结肠炎 (UC) 的小鼠模型中研究Sishen Pill (SSP) 的治疗疗效.
阐明SSP对UC的行动中涉及的潜在药理路径.

主要方法:

使用UPLC-MS/MS进行SSP的植物化学分析.
在小鼠中使用硫酸 (DSS) 诱导UC.
评估临床,炎症和屏障完整性标记物;RNA测序和网络药理学以确定途径,包括AGE-RAGE-NLRP3轴验证.

主要成果:

SSP治疗显著缓解了UC症状,包括体重减轻,结肠缩短和疾病活动.
SSP降低了促炎性细胞因子 (IL-6,IL-1β) 和增加了抗炎性IL-13,恢复了肠道屏障蛋白 (occludin,claudin-1).
AGE-RAGE-NLRP3轴被确定为核心调节途径,在体内和体外得到证实.

结论:

西申药丸 (SSP) 显示出对性结肠炎 (UC) 的显著保护作用.
通过抑制AGE-RAGE-NLRP3信号通路,SSP改善了UC,突出了其治疗潜力.

关键词:

炎症性细胞因子是炎症性细胞因子.梅萨拉辛 (Mesalazine) 是一种可怕的药物.通过RNA-seq分析进行分析.这种药丸是西申的药丸.传统的中国医学是传统的中国医学.性结肠炎是一种

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