在重症患者中早期诊断深静脉血栓 (DETECT) 试验:随机对照试验的协议
Yaseen M Arabi1, Farhan Alenezi2, Fahad Al-Hameed3
1Intensive Care Department, King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Reserach Center, Riyadh, Saudi Arabia yaseenarabi@yahoo.com.
BMJ open
|October 29, 2025
概括
这项研究旨在调查定期的超声波是否能在重症患者中更早地检测出深静脉血栓症 (DVT),旨在改善生存率. 结果将决定这种监测策略是否有利于重症监护室 (ICU) 患者.
科学领域:
- 临界护理医学 临界护理医学
- 血管外科 血管外科
- 诊断成像 诊断成像 诊断成像
背景情况:
- 深静脉血栓症 (DVT) 在重症患者中往往没有被检测出来.
- 在重症监护室 (ICU) 患者中,对DVT进行例行超声波监测的益处尚不清楚.
- DETECT试验调查了早期DVT检测对患者结局的影响.
研究的目的:
- 评估每周两次进行双边下肢超声监测对重症患者90天死亡率的影响.
- 评估二次结果,包括下肢近端DVT,肺栓塞和出血事件.
- 为了确定早期DVT检测是否改善了医疗,外科和创伤ICU人群的结果.
主要方法:
- 一个国际,并行组,开放标签,随机化试验 (DETECT试验).
- 在沙特阿拉伯和科威特的14家医院招募1800名重症成年人.
- 分配到每周两次的双边下肢超声波或通常的护理.
主要成果:
- 截至2025年4月8日,来自14个中心的711名患者已被录取.
- 第一个中间分析于2025年5月14日进行.
- 招聘正在进行中,预计将于2026年12月完成.
结论:
- 在DETECT试验中,正在积极招募患者,以确定在重症患者群体中对DVT的超声波监测的有效性.
- 预计这些发现将为ICU中DVT管理的临床实践指南提供信息.
- 该研究旨在提供有关早期DVT检测对患者死亡率和发病率的影响的关键数据.
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