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Peripheral Nervous System: Ganglia and Nerves01:24

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The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease IV: Nursing Management01:26

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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周围神经病变 - 周围神经病变

Elisa Frisaldi1

  • 1Department of Neurology, Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Medicine Essen, University of Duisburg-Essen, Essen, Germany.

Handbook of clinical neurology
|October 29, 2025
PubMed
概括
此摘要是机器生成的。

本综述探讨了外围神经病变中的安慰剂和无效疗法效应. 在特定的疾病中发现了显著的影响,例如神经性胸腔切除术并发症和慢性炎症性脱髓化多神经病变 (CIPD).

关键词:
手管道综合征是什么意思慢性炎症性脱髓化的多神经病变.吉兰·巴雷综合征 吉兰·巴雷综合征胸腔切除术的神经病变并发症没有假药效应的效应.没有安慰剂反应.疼痛性糖尿病神经病变是一种神经病变.周围神经病变是一种神经病变.避孕药效应 避孕药效应对安慰剂的反应术后性神经疼痛 术后性神经疼痛

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科学领域:

  • 神经学 神经学
  • 临床试验 临床试验
  • 精神病体医学是一种精神病体医学.

背景情况:

  • 周围神经病变包括各种影响神经功能的疾病.
  • 受患者期望和背景影响的安慰剂和无效疗法效应在疼痛和神经系统疾病中越来越多地受到研究.
  • 对外围神经病变中这些影响的研究正在扩大,特别是在过去的七年里.

研究的目的:

  • 提供对外围神经病变的概述,其中已经研究了安慰剂和nocebo反应/效应.
  • 以突出新兴研究这些影响在特定的神经病症条件.
  • 确定需要进一步研究的领域,以改善临床试验.

主要方法:

  • 在外围神经病变中研究安慰剂和nocebo效应的研究文献综述.
  • 专注于过去七年出版的原创研究.
  • 分析特定疾病,包括疼痛性糖尿病神经病变,后神经疼痛,胸切除术的神经病变并发症,手足道综合征,吉林-巴雷综合征和慢性炎症性脱髓性多神经病变 (CIPD).

主要成果:

  • 在胸切除术的神经病变并发症和慢性炎症性脱髓性多神经病变 (CIPD) 中报告了显著的安慰剂效应.
  • 治疗期望被确定为胸切除术神经病变并发症治疗结果的预测因素.
  • 对于大多数其他外围神经病变,关于安慰剂和非安慰剂效应的数据有限.

结论:

  • 安慰剂和安慰剂效应在某些外围神经病变中发挥作用,特别是胸切除术和CIPD的神经病变并发症.
  • 未来的研究应该优先考虑上下文因素,包括无治疗臂,并控制外围神经病变的临床试验中的基线共变量.
  • 需要进行进一步的研究,以充分理解和利用整个外围神经病变的范围内的安慰剂/安慰剂现象.