三甘油糖指数与慢性病风险之间的关联:元分析
Yu Zhang1, Rongrong Yuan2, Dandan Li2
1Department of Nephrology, Huaihe Hospital of Henan University, Kaifeng, China.
Renal failure
|October 29, 2025
概括
甘油三糖 (TyG) 指数是胰岛素抵抗的标志物,预测患慢性病 (CKD) 的风险更高. 这种关联在短期后续研究中尤为明显.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢综合征是代谢综合征的一种.
- 流行病学 流行病学
背景情况:
- 胰岛素抵抗是代谢功能障碍的一个关键因素.
- 甘油三糖指数 (TyG) 是一种被验证的胰岛素耐药性的替代标记.
- 关于TyG指数和慢性病 (CKD) 发病率的现有纵向数据有限.
研究的目的:
- 评估基线TyG指数与成年人中CKD发病率之间的关联.
- 综合对TyG指数对CKD发展的预测价值的纵向证据.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science) 进行了系统的文献搜索,截至2025年3月.
- 包括研究TyG指数和CKD风险的纵向队列研究.
- 随机效应的元分析被用于组合风险比率 (RRs) 和95%置信区间 (CI).
主要成果:
- 分析了12项队列研究 (n=58,838) 的13个数据集.
- 一个高的基线TyG指数与增加的CKD发病率显著相关 (RR: 1.44,95% CI: 1.33-1.56).
- 在敏感性和前性分析中,这种关联仍然很强,在较短的随访时间 (<4年) 中观察到更强的效应.
结论:
- 提升的TyG指数是成年人发生CKD的独立预测指标.
- 泰格指数证明了对CKD的早期风险分层的有用性.
- 它的预测价值在较短的随访期间显得更加明显.
相关概念视频
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
185
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
185
Chronic Kidney Disease III: Interprofessional Care
333
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
333
Chronic Kidney Disease I: Introduction
556
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
556
Chronic Kidney Disease II: Clinical Manifestations
543
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
543
Oral Hypoglycemic Agents: Biguanides and Glitazones
581
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
581
Overview of Lipid Metabolism
4.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.8K

