儿童时期的MASLD作为一个超出肝脏的多系统健康挑战
Marica Esposito1, Ida Rimauro1, Vittoria Frattolillo1
1Department of Woman, Child, and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', Naples, Italy.
Trends in endocrinology and metabolism: TEM
|October 29, 2025
概括
儿童代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益关注的问题,不仅影响肝脏,还影响骨健康,生长和精神健康. 早期检测和多学科护理对于管理这种儿科多系统疾病至关重要.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 儿童肥胖和2型糖尿病正在增加,导致儿科代谢功能障碍相关脂肪性肝病 (MASLD) 的增加.
- 除了肝脏之外,MASLD对健康造成重大负担,影响心脏代谢健康.
- 新出现的证据强调了儿科MASLD的肝外并发症,包括骨健康,生长,睡眠和神经行为问题.
研究的目的:
- 探索童年开始的MASLD对长期健康的多方面的影响.
- 强调MASLD是一种多系统性疾病,具有显著的肝外后果.
- 突出需要提高临床意识和对MASLD机制和并发症的研究.
主要方法:
- 文献综述和关于儿科MASLD的当前证据的综合.
- 对肝脏和肝外并发症的新兴数据的分析.
- 探索与儿科MASLD相关的长期健康轨迹和心理社会风险.
主要成果:
- 儿科MASLD与骨质健康受损,生长缺陷,睡眠障碍以及抑郁和焦虑等神经行为问题有关.
- 马斯尔德的进展可能会增加脂肪肝炎,纤维化和潜在的肝癌和肝癌的风险.
- 肝外并发症显著影响受影响儿童的长期健康和心理社会福祉.
结论:
- 儿科MASLD是一种多系统性疾病,具有深远的长期健康影响.
- 早期检测,提高临床意识和协调的多学科护理对于改善结果至关重要.
- 迫切需要进一步研究儿科MASLD的机制和并发症.
更多相关视频
相关概念视频
Diseases of the Liver and Gallbladder
1.8K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.8K
Inborn Errors of Metabolism
691
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
691
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
179
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
179
Other Disorders of Digestive System
1.4K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.4K
Liver Physiology
3.5K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.5K
Liver Regeneration
4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K


