维生素D代谢物比率的增加水平可以防止从岛屿自身免疫到T1D的进展
Patrick M Carry1,2,3, Soojeong Kim2,4, Nicole L Zwick2
1Department of Orthopedics, University of Colorado Anschutz Medical Campus.
The Journal of clinical endocrinology and metabolism
|October 29, 2025
概括
较高的维生素D代谢物比率 (VMR) 可以防止1型糖尿病 (T1D) 的进展. 这表明VMR可能会减少炎症,为T1D预防策略提供了一个新的途径.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 较高的25-基维生素D (25OHD) 水平显示出对小岛自身免疫 (IA) 的保护,小岛自身免疫是1型糖尿病 (T1D) 的前体.
- 25OHD及其代谢物在IA过渡到T1D中的特定作用尚不清楚.
研究的目的:
- 调查维生素D代谢物及其比例与IA的T1D进展之间的关联.
- 探索维生素D代谢物比率作为T1D风险的功能生物标志物的潜力.
主要方法:
- 在使用LC-MS/MS的血中量化多种维生素D代谢物 (D3,25OHD2,3-epi-25OHD3,25OHD3,24,25(OH) 2D3,1α,25(OH) 2D3).
- 计算了维生素D代谢物比率 (VMR) 和epimer比率.
- 分析了从年轻人糖尿病自身免疫研究 (DAISY) 队列参与者的子集中代谢物水平和基因表达之间的相关性.
主要成果:
- 在IA血清转化时,较高的VMR (HR:0.65) 和24,25(OH) 2D3水平 (HR:0.72) 与进展到T1D的风险降低有关.
- 根据年龄,季节,HLA基因型和祖先进行了调整.
- 功能分析表明,较高的VMR与炎症途径基因表达的减少相关,特别是中性粒细胞透.
结论:
- 较高的VMR,反映了维生素D状态的功能性测量,证明了对T1D进展的保护作用.
- 这种保护作用可能是通过抑制炎症通路的调节来调节的.
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